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You are here: Home » News » Jesuit Agendas » Health Care News » Vaccines » Spike Proteins » Long-Term Dangers of Experimental mRNA Shots

Long-Term Dangers of Experimental mRNA Shots

September 6, 2021 8:00 PM By Dr Joseph Mercola Leave a Comment

Originally published by Mercola.com and republished on his Private Substack.


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STORY AT-A-GLANCE

  • mRNA-based COVID shots have used codon optimization to improve protein production. A codon consists of three nucleotides, and nucleotides are the building blocks of DNA. Use of codon optimization virtually guarantees unexpected results
  • Replacing rare codons must be done judiciously, as rarer codons can have slower translation rates and a slowed-down rate is actually necessary to prevent protein misfolding
  • Stop codons, when present at the end of an mRNA coding sequence, signals the termination of protein synthesis. According to a recent paper, both Pfizer and Moderna selected suboptimal stop codons
  • The COVID shots induce spike protein at levels unheard of in nature, and the spike protein is the toxic part of the virus responsible for the most unique effects of the virus, such as the blood clotting disorders, neurological problems and heart damage. To expect the COVID shot to not produce these kinds of effects would be rather naïve
  • Other significant threats include immune dysfunction and the flare-up of latent viral infections such as herpes and shingles. Coinfections, in turn, could accelerate other diseases. Herpes viruses, for example, have been implicated as a cause of both AIDS and chronic fatigue syndrome

“Let’s start with a thought experiment: If an engineering design flaw exists and no one measures it, can it really injure people or kill them?” a Twitter user named Ehden writes.1 He goes on to discuss an overlooked aspect of the COVID mRNA shots, something called “codon optimization,” which virtually guarantees unexpected results. Ehden explains:2

“Trying to tell your body to generate proteins is hard for many reasons. One of them is the fact that when you try to run the protein information via ribosomes which process that code and generate the protein, it can be very slow or can get stuck during the process.

Luckily, scientists found a way to overcome this problem, by doing code substitution: instead of using the original genetic code to generate the protein, they changed the letters in the code so the code would be optimized. This is known as Codon Optimization.”

COVID Shots Use Codon Optimization

A codon consists of three nucleotides, and nucleotides are the building blocks of DNA. An August 2021 article in Nature Reviews Drug Discovery, addressed the use of codon optimization as follows:3

“The open reading frame of the mRNA vaccine is the most crucial component because it contains the coding sequence that is translated into protein.

Although the open reading frame is not as malleable as the non-coding regions, it can be optimized to increase translation without altering the protein sequence by replacing rarely used codons with more frequently occurring codons that encode the same amino acid residue.

For instance, the biopharmaceutical company CureVac AG discovered that human mRNA codons rarely have A or U at the third position and patented a strategy that replaces A or U at the third position in the open reading frame with G or C. CureVac used this optimization strategy for its SARS-CoV-2 candidate CVnCoV …

Although replacement of rare codons is an attractive optimization strategy, it must be used judiciously. This is because, in the case of some proteins, the slower translation rate of rare codons is necessary for proper protein folding.

To maximize translation, the mRNA sequence typically incorporates modified nucleosides, such as pseudouridine, N1-methylpseudouridine or other nucleoside analogues. Because all native mRNAs include modified nucleosides, the immune system has evolved to recognize unmodified single-stranded RNA, which is a hallmark of viral infection.

Specifically, unmodified mRNA is recognized by pattern recognition receptors, such as Toll-like receptor 3 (TLR3), TLR7 and TLR8, and the retinoic acid-inducible gene I (RIGI) receptor. TLR7 and TLR8 receptors bind to guanosine- or uridine-rich regions in mRNA and trigger the production of type I interferons, such as IFNα, that can block mRNA translation.

The use of modified nucleosides, particularly modified uridine, prevents recognition by pattern recognition receptors, enabling sufficient levels of translation to produce prophylactic amounts of protein.

Both the Moderna and Pfizer–BioNTech SARS-CoV-2 vaccines … contain nucleoside-modified mRNAs. Another strategy to avoid detection by pattern recognition receptors, pioneered by CureVac, uses sequence engineering and codon optimization to deplete uridines by boosting the GC content of the vaccine mRNA.”

Much of this information was previously reviewed in my interview with Stephanie Seneff, Ph.D., and Judy Mikovits, Ph.D. You can’t see the article but the video is embedded above. This study was published well after our interview and merely confirms what Seneff and Mikovits have unraveled in their research.

According to Ehden, 60.9% of the codons in COVID shots have been optimized, equivalent to 22.5% of the nucleotides, but he doesn’t specify which shot he’s talking about, or exactly where the data came from.

That all mRNA COVID shots are using codon optimization to one degree or another is clear, however. A July 2021 article4 in the journal Vaccines specifically evaluates and comments on the Pfizer/BioNTech and Moderna mRNA shots, noting:

“The design of Pfizer/BioNTech and Moderna mRNA vaccines involves many different types of optimizations … The mRNA components of the vaccine need to have a 5′-UTR to load ribosomes efficiently onto the mRNA for translation initiation, optimized codon usage for efficient translation elongation, and optimal stop codon for efficient translation termination.

Both 5′-UTR and the downstream 3′-UTR should be optimized for mRNA stability. The replacement of uridine by N1-methylpseudourinine (Ψ) complicates some of these optimization processes because Ψ is more versatile in wobbling than U. Different optimizations can conflict with each other, and compromises would need to be made.

I highlight the similarities and differences between Pfizer/BioNTech and Moderna mRNA vaccines and discuss the advantage and disadvantage of each to facilitate future vaccine improvement. In particular, I point out a few optimizations in the design of the two mRNA vaccines that have not been performed properly.”

What Can Go Wrong?

One key take-home from the Nature Reviews Drug Discovery article5 cited above is that replacing rare codons “must be used judiciously,” as rarer codons can have slower translation rates and a slowed-down rate is actually necessary to prevent protein misfolding.

The spike protein is the toxic part of the virus responsible for the most unique effects of the virus, such as the blood clotting disorders, neurological problems and heart damage. To expect the COVID shot to not produce these kinds of effects would be rather naïve.

A (adenine) and U (uracil) in the third position are rare, and the COVID shots replace these A’s and U’s with G’s (guanine) or C’s (cytosine). According to Seneff, this switch results in a 1,000-fold greater amount of spike protein compared to being infected with the actual virus.

What could go wrong? Well, just about anything. Again, the shot induces spike protein at levels unheard of in nature (even if SARS-CoV-2 is a “souped up” manmade concoction), and the spike protein is the toxic part of the virus responsible for the most unique effects of the virus, such as the blood clotting disorders, neurological problems and heart damage.

So, to expect the COVID shot to not produce these kinds of effects would be rather naïve. The codon switches might also result in protein misfolding, which is equally bad news. As explained by Seneff in our previous interview:

“The spike proteins that these mRNA vaccines are producing … aren’t able to go into the membrane, which I think is going to encourage it to become a problematic prion protein. Then, when you have inflammation, it upregulates alpha-synuclein [a neuronal protein that regulates synaptic traffic and neurotransmitter release].

So, you’re going to get alpha-synuclein drawn into misfolded spike proteins, turning into a mess inside the dendritic cells in the germinal centers in the spleen. And they’re going to package up all this crud into exosomes and release them. They’re then going to travel along the vagus nerve to the brainstem and cause things like Parkinson’s disease.

So, I think this is a complete setup for Parkinson’s disease … It’s going to push forward the date at which someone who has a propensity towards Parkinson’s is going to get it.

And it’s probably going to cause people to get Parkinson’s who never would have gotten it in the first place — especially if they keep getting the vaccine every year. Every year you do a booster, you bring the date that you’re going to get Parkinson’s ever closer.”

Immune Dysfunction and Viral Flare-Ups

Other significant threats include immune dysfunction and the flare-up of latent viral infections, which is something Mikovits has been warning about. In our previous interview, she noted:

“We use poly(I:C) [a toll-like receptor 3 agonist] to signal the cell to turn on the type I interferon pathway, and because [the spike protein your body produces in response to the COVID shot] is an unnatural synthetic envelope, you’re not seeing poly(I:C), and you’re not [activating] the Type I interferon pathway.

You’ve bypassed the plasmacytoid dendritic cell, which combined with IL-10, by talking to the regulatory B cells, decides what subclasses of antibodies to put out. So, you’ve bypassed the communication between the innate and adaptive immune response. You now miss the signaling of the endocannabinoid receptors …

A large part of Dr. [Francis] Ruscetti’s and my work over the last 30 years has been to show you don’t need an infectious transmissible virus — just pieces and parts of these viruses are worse, because they also turn on danger signals. They act like danger signals and pathogen-associated molecular patterns.

So, it synergistically leaves that inflammatory cytokine signature on that spins your innate immune response out of control. It just cannot keep up with the myelopoiesis [the production of cells in your bone marrow]. Hence you see a skew-away from the mesenchymal stem cell towards TGF-beta regulated hematopoietic stem cells.

This means you could see bleeding disorders on both ends. You can’t make enough firetrucks to send to the fire. Your innate immune response can’t get there, and then you’ve just got a total train wreck of your immune system.”

We’re now seeing reports of herpes and shingles infection following COVID-19 injection, and this is precisely what you can expect if your Type I interferon pathway is disabled. That’s not the end of your potential troubles, however, as these coinfections could accelerate other diseases as well.

For example, herpes viruses have been implicated as a trigger of both AIDS6 and myalgic encephalomyelitis7 (chronic fatigue syndrome or ME-CFS). According to Mikovits, these diseases don’t appear until viruses from different families partner up and retroviruses take out the Type 1 interferon pathway. Long term, the COVID mass injection campaign may be laying the foundation for a rapidly approaching avalanche of a wide range of debilitating chronic illnesses.

Are COVID Shots Appropriately Optimized?

As noted in the Vaccines article cited earlier, the codon optimization in the Pfizer and Moderna shots could be problematic:8

“As mammalian host cells attack unmodified exogeneous RNA, all U nucleotides were replaced by N1-methylpseudouridine (Ψ). However, Ψ wobbles more in base-pairing than U and can pair not only with A and G, but also, to a lesser extent, with C and U.

This is likely to increase misreading of a codon by a near-cognate tRNA. When nucleotide U in stop codons was replaced by Ψ, the rate of misreading of a stop codon by a near-cognate tRNAs increased.

Such readthrough events would not only decrease the number of immunogenic proteins, but also produce a longer protein of unknown fate with potentially deleterious effects …

The designers of both vaccines considered CGG as the optimal codon in the CGN codon family and recoded almost all CGN codons to CGG … [M]ultiple lines of evidence suggest that CGC is a better codon than CGG. The designers of the mRNA vaccines (especially mRNA-1273) chose a wrong codon as the optimal codon.”

The paper also points out the importance of vaccine mRNA to be translated accurately and not merely effectively, because if the wrong amino acids are incorporated, it can confuse your immune system and prevent it from identifying the correct targets.

Accuracy is also important in translation termination, and here it comes down to selecting the correct stop codons. Stop codons (UAA, UAG or UGA), when present at the end of an mRNA coding sequence signals the termination of protein synthesis.

According to the author, both Pfizer and Moderna selected less than optimal stop codons. “UGA is a poor choice of a stop codon, and UGAU in Pfizer/BioNTech and Moderna mRNA vaccines could be even worse,” she says.

What Health Problems Can We Expect to See More Of?

While the variety of diseases we may see a rise in as a result of this vaccination campaign are myriad, some general predictions can be made. We’ve already seen a massive uptick in blood clotting disorders, heart attacks and stroke, as well as heart inflammation.

More long term, Seneff believes we’ll see a significant rise in cancer, accelerated Parkinson’s-like diseases, Huntington’s disease, and all types of autoimmune diseases and neurodegenerative disorders.

Mikovits also suspects many will develop chronic and debilitating diseases and will die prematurely. At highest risk, she places those who are asymptomatically infected with XMRVs and gammaretroviruses from contaminated conventional vaccines. The COVID shot will effectively accelerate their death by crippling their immune function. “The kids that are highly vaccinated, they’re ticking time bombs,” Mikovits said in my May 2021 interview.

What Are the Options?

While all of this is highly problematic, there is hope. From my perspective, I believe the best thing you can do is to build your innate immune system. To do that, you need to become metabolically flexible and optimize your diet. You’ll also want to make sure your vitamin D level is optimized to between 60 ng/mL and 80 ng/mL (100 nmol/L to 150 nmol/L).

I also recommend time-restricted eating, where you eat all your meals for the day within a six- to eight-hour window. Time-restricted eating will also upregulate autophagy, which may help digest and remove spike protein. Avoid all vegetable oils and processed foods. Focus on certified-organic foods to minimize your glyphosate exposure.

Sauna therapy may also be helpful. It upregulates heat shock proteins, which can help refold misfolded proteins. They also tag damaged proteins and target them for removal.

Sources and References

  • 1, 2 Twitter Ehden August 15, 2021
  • 3, 5 Nature Reviews Drug Discovery August 25, 2021
  • 4 Vaccines July 2021; 9(7): 734
  • 6 Journal of Antimicrobial Chemotherapy 1996 37. Suppl B, 87-95
  • 7 ImmunoHorizons April 1, 2020
  • 8 Vaccines July 2021; 9(7): 734, Introduction


Originally published by Mercola.com.

Author: Dr Joseph Mercola

Dr. Joseph Mercola is the founder of Mercola.com. An osteopathic physician, best-selling author and recipient of multiple awards in the field of natural health, his primary vision is to change the modern health paradigm by providing people with a valuable resource to help them take control of their health.

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  • James Bailey on Prophetic chart could be showing macro view of crypto winter aheadThanks for sharing those dreams Frank. The bullish pattern for SPX that you felt bummed that it was broken sounds like what I'm expecting for the next month or so with a downturn starting in mid Septe…
  • LovetheLord on America’s Plan for A New World System (words inspired by God)It's okay to laugh, I believe. That part lifted my spirits. We need some few seconds relief from the stress!
  • faith on I remember thinking “Why did I do this? Now I’m going to die.”I have a different take on this dream and in my opinion it's about the crypto market. One needs to ask themselves the significance of her being a red head and going upstairs. What would that scene hav…
  • lisa on America’s Plan for A New World System (words inspired by God)God bless you Caroline and thank you for this word. This confirms what my spirit has been showing me. The christians that believe this can be overturned are going to be very surprised. We are in the e…
  • Carla on A Season of Divine DistinctionThis was on point, thanks for sharing. Passing this on !! 🙏
  • PaulAu on I remember thinking “Why did I do this? Now I’m going to die.”MITIGATION PROTOCOL - FYI. Last year, I had a very interesting visit with a doctor who was recommended by the Covid Medical Network, Australia. Her take on vaccines: She said that they all had side ef…
  • Frank on Prophetic chart could be showing macro view of crypto winter aheadJames, at risk of this getting buried among so many replies here, I did want to share a very clear dream I had a few days ago on the SP500. In my dream I was watching the evening news and saw the dail…
  • James Bailey on Prophetic chart could be showing macro view of crypto winter aheadI had been thinking it was coming soon but received warnings that it's further out on the timeline. I also received an update that the bottom is closer to 3658, not 3690. My current target date is Sep…
  • Nobody on Prophetic dream reveals coming crash in crypto currency pricesWell, can't say for sure, but need to bring it to your attention that, there is a chance your dream may be about to unfold in a month or 2 in this mid-late summer 2022 ..... your dream did mention an…
  • Katie on Liars, Propagandists and The Great ResetThe evil woman spreading the psudeo psychology to these saps are the real villains
  • N.Newton on Prophetic dream shows Bitcoin stuck in heavy trafficIt could be next summer but I feel something weird going to happen soon. There must be a reason why CCP banned BTC. If this hack occurred, it could be catastrophic. 😎God bless
  • Phil - Sydney on I remember thinking “Why did I do this? Now I’m going to die.”Thanks James I took the jab because I had major expenses and ongoing mortgage payments. Transport NSW would not let me work without the jab. Thanks the Lord that I have been kept well. This policy is…
  • Dana R on I saw US currency bills on the ground all over the place and they were frozen in ice.Hi Audrey, Whenever the Lord gives me visions of snow, ice or hail, He is referring to deception. I wrote about this in my testimony “Snow Job”.
  • RealPatriot2020 on “God is doing something with His Chosen and Elect.”Please understand I am saying this out of love for my fellow brothers and sisters in Christ. I just learned about the true nature of the Talmud a year ago, and after reading some verses I became angry…
  • Peggy on Get in the secret place and find His voice again.Thank you and Amen
  • Michelle gibson on Get in the secret place and find His voice again.Amen
  • Marcio on Bitcoin dreams reveal low flash crash prices and $25,000Mysa, thank you for sharing. November and December could be low for BTC after the current bear flag has completed.
  • Cunny Fred on Prophetic chart could be showing macro view of crypto winter aheadJames, the 3690 that you saw before might just happen, because it is technically possible. SPX might retrace, to make contact with the current "bull flag", possibly down to the 3700 range. James, you…
  • Melinda on I remember thinking “Why did I do this? Now I’m going to die.”I haven’t taken nor do I advocate the vaccines and I was a public health nurse before the Lord convicted me of the evil business. Mark 7:15 states: There is nothing that enters a man from outside whic…
  • Mysa on Bitcoin dreams reveal low flash crash prices and $25,000Let me explain. On Monday 1st of August, at around 11PM in the night, I saw this date 18th November in a dream. It was written in Red. For some reason, just seeing that date in the dream caused me to…
  • David Powell on I saw US currency bills on the ground all over the place and they were frozen in ice.Blessings from Alaska. 2 things avision standing in parking lot $100 bill blowing in the wind nobody cared Heard question how could it be? Obadiah 1 readd lick headlines of news
  • James Bailey on I remember thinking “Why did I do this? Now I’m going to die.”I have not found any scriptures supporting the claim that the covid serum dooms recipients for eternity, although I believe it's pure poison that has already sent many into eternity prematurely. I hav…
  • James Bailey on Prophetic chart could be showing macro view of crypto winter aheadWithout dates or prices, it's challenging to put prophetic insights into the correct sequence but over the past couple of weeks, I've received corrections and new insights showing the next drop hits b…
  • Warrior in Christ on What He promised of old He is still promising today.Yes as amen thank you Lord Jesus !
  • Marcio on Bitcoin dreams reveal low flash crash prices and $25,000Significant bearish BTC indicators: This Chart SCARES Me – An HONEST Hot Take By Crypto Crew University https://www.youtube.com/watch?v=wRks4cYSEa0
  • mem on I remember thinking “Why did I do this? Now I’m going to die.”In reviewing some of the dreams that I and my family have had it became clear that sometimes we are shown what we avoided or what would have happened or what would happen to us or others...if we/they…
  • Fionnola Morris on The Bite of the SerpentWith the exception of some people, usually elderly imprisoned in “care homes”, with dementia or immobile, or unconscious in hospital, people with learning difficulties and with the exception of Commun…
  • Fionnola Morris on The Bite of the SerpentDon’t the Minor Prophets (Zechariah) state only a remnant of God’s people, the Jews will remain, especially as they and the rest of us believers (Revelation) will be the anti-Christ’s main target? Yes…
  • Fionnola Morris on I saw US currency bills on the ground all over the place and they were frozen in ice.The only trouble is, you can’t eat gold and silver, or real estate, unless you plant a vegetable garden, Moreover, you will only be able to exchange your gold and silver - if it is in your possession…
  • Fionnola Morris on I saw US currency bills on the ground all over the place and they were frozen in ice.Currency crashes and there is the ‘bail IN’ legislation, enacted in 2016 for the EU countries. Only last week, I believe I heard from God on waking about removing my cash from my account - with some u…
  • Rett on I saw US currency bills on the ground all over the place and they were frozen in ice.I had a dream June I think that I went to the bank and asked for 200 dollars and they would only give me 100
  • Edg on I saw US currency bills on the ground all over the place and they were frozen in ice.I do believe we will see Bank Runs in America , crooked Banksters will Steal , hold , your money and many banks will go Down and Out taking people's money withn them also I do Believe we will see High…
  • John on Prophetic chart could be showing macro view of crypto winter aheadHi James, are you still expecting 3690 in the next several days? Thanks.
  • Frank on I saw US currency bills on the ground all over the place and they were frozen in ice.Here's another interpretation: Jim Rickards, former economist for the Pentagon and respected financial expert, in his book "The Road to Ruin," describes a future scenario he calls "Ice-Nine." He descr…
  • William on I saw US currency bills on the ground all over the place and they were frozen in ice.I’ve shared this dream before, but I saw many different fiat currencies going through a paper shredder, not sure which currencies they were, apart from one, the Euro. I saw the Euro go half way throug…
  • Mysa on Bitcoin dreams reveal low flash crash prices and $25,000November 18...something will happen to bitcoin.
  • Michelle gibson on “A Counteroffensive is on the March.”I agree, the Lord told me a few weeks ago to hold the line. And that is what we do
  • Michelle gibson on God is connecting the dots that have felt spread out and confusingAmen!
  • Michelle gibson on I saw US currency bills on the ground all over the place and they were frozen in ice.I had a short dream where I was with a group of people standing in front of a shipping container and when I opened it it was full of U.S. money all shredded up. And I woke up. I believe since this mon…
  • LynneNZ on I remember thinking “Why did I do this? Now I’m going to die.”I prayed so hard over these vaccines as Christians all around me were taking them. The verse God gave me was Matt 7 v 21, Not everyone who says to me Lord, Lord, will enter the Kingdom of Heaven, but…
  • Marcio on Bitcoin dreams reveal low flash crash prices and $25,000I also want to thank you, SW, for continuing to post your crypto dreams here. We appreciate you. God bless.
  • LovetheLord on I remember thinking “Why did I do this? Now I’m going to die.”This is a hard topic, full of unknowns. I read a prophecy here or elsewhere years ago that, if I recall correctly, those who made the vaccines separated them into 3 groups: those that caused blood clo…
  • Glenn Clark on Bitcoin dreams reveal low flash crash prices and $25,000Thanks SW, I always appreciate your posts. I'm wondering how this relates or is connected to your dreams of $4 & $10. I've heard so many prophecies on the BTC flash crash to zero so I wonder if th…
  • Josh on God is connecting the dots that have felt spread out and confusingAmen, I know this is true. God has been preparing us for our whole lives. I can sense that things are coming into focus but is not quite there yet. I know clarity is ours.
  • deborah2221 on Some don’t realize how demonic jealousy and envy is.Envy compels the heart to try relentlessly to tear someone else down. If envy is in the heart towards someone, it prevents love towards that person. God can not act in the heart in where envy is. It i…
  • deborah2221 on We Are About To Experience An Absolutely Epic Housing Crash The Likes Of Which America Has Never Seen BeforeFor Sale housing is being bought up by huge investment banks. They will hold it and keep prices rising. The commenter who said buy a rural home and land is on target. Do what you can to get out of cit…
  • Edg on How Corrupt is Ukrainian President Volodymyr Zelensky?Yes a lot of Crooks all over the world , here in USA will FALL DOWN and face the Law for their Crimes here in America we GOT THIEVES , CROOKS RUNNING Things in the WH , congress, senate, and the chine…
  • Peggy on Elitists’ Goal: Wipe Out Good FoodThank you for putting out the facts I Was just telling a friend of mine What soy protein isolate is After he told me it was one of the listed ingredients in his Veggie hot dogs Soy protein isolate is…
  • Phil - Sydney on Current Events – Fulfilling Prophetic Words Part 1Thanks Caroline- very relevant
  • Miriam Banting on Current Events – Fulfilling Prophetic Words Part 1Hi Caroline, you're right about Jeff Byerly he mentions the Ronald Reagan and the Abraham Lincoln being damaged/blown up. Secondly I agree with your/God's viewpoint on Russia Ukrainian war. The Russia…

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