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You are here: Home » News » Jesuit Agendas » Health Care News » Vaccines » Letter to Physicians: Four New Scientific Discoveries Regarding the Safety and Efficacy of COVID-19 Vaccines

Letter to Physicians: Four New Scientific Discoveries Regarding the Safety and Efficacy of COVID-19 Vaccines

July 13, 2021 8:07 AM By Centre for Research on Globalization Leave a Comment

Originally published by Globalresearch.ca.


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Doctors for Covid Ethics has sent the following letter to tens of thousands of doctors in Europe, summarising four recent scientific findings critical to the COVID-19 vaccination program. The letter explains each finding as it relates to the biology of COVID-19 vaccines, including interactions with the immune system.

Taken together, the letter warns that these new pieces of evidence force all physicians administering COVID-19 vaccines to re-evaluate the merits of COVID-19 vaccination, in the interests of their own ethical standing, and their patients’ safety and health.

A video explanation of the underlying immunology by Professor Sucharit Bhakdi MD is here, with German subtitles here.


Dear Colleague:

Four recent scientific discoveries are herewith brought to your urgent attention. They alter the entire landscape of the COVID-19 pandemic, and they force us to reassess the merits of vaccination against SARS-CoV-2.

Summary

Rapid and efficient memory-type immune responses occur reliably in virtually all unvaccinated individuals who are exposed to SARS-CoV-2. The effectiveness of further boosting the immune response through vaccination is therefore highly doubtful. Vaccination may instead aggravate disease through antibody-dependent enhancement (ADE).

Discovery 1: SARS-CoV-2 spike protein circulates shortly after vaccination

SARS-CoV-2 proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of Moderna mRNA-1273 vaccine [1]. With 11 of the 13, the SARS-CoV-2 spike protein was detected in the blood within only one day after the first vaccine injection.

Significance. Spike protein molecules were produced within cells that are in contact with the bloodstream—mostly endothelial cells—and released into the circulation. This means that a) the immune system will attack those endothelial cells, and b) the circulating spike protein molecules will activate thrombocytes. Both effects will promote blood clotting. This explains the many clotting-related adverse events—stroke, heart attack, venous thrombosis—that are being reported after vaccination.

Discovery 2: Rapid, memory-type antibody response after vaccination

Several studies have demonstrated that circulating SARS-CoV-2-specific IgG and IgA antibodies became detectable within 1-2 weeks after application of mRNA vaccines [1–3].

Significance. Rapid production of IgG and IgA always indicates a secondary, memory-type response that is elicited through re-stimulation of pre-existing immune cells. Primary immune responses to novel antigens take longer to evolve and initially produce IgM antibodies, which is then followed by the isotype switch to IgG and IgA.

A certain amount of IgM was indeed detected alongside IgG and IgA in some studies [1,4]. Importantly, however, IgG rose faster than IgM [4], which confirms that the early IgG response was indeed of the memory type. This memory response indicates pre-existing, cross-reactive immunity due to previous infection with ordinary respiratory human coronavirus strains. The delayed IgM response most likely represents a primary response to novel epitopes which are specific to SARS-CoV-2.

Memory-type responses have also been documented with respect to T-cell-mediated immunity [5–7]. Overall, these findings indicate that our immune system efficiently recognizes SARS-CoV-2 as “known” even on first contact. Severe cases of the disease thus cannot be ascribed to lacking immunity. Instead, severe cases might very well be caused or aggravated by pre-existing immunity through antibody-dependent enhancement (ADE, see below).

Discovery 3: SARS-CoV-2 elicits robust adaptive immune responses regardless of disease severity

Serum antibody profiles were reported for 203 individuals following SARS-CoV-2 infection [8]. 202 (>99%) of the participants exhibited SARS-CoV-2 specific antibodies. With 193 individuals (95%), these antibodies prevented SARS-CoV-2 infection in cell culture and also inhibited binding of the spike protein to the ACE2 receptor. Furthermore, CD8+ T-cell responses specific for SARS-CoV-2 were clear and quantifiable in 95 of 106 (90%) HLA-A2-positive individuals.

Significance. This study confirms the above assertion that the immune response to initial contact with SARS-CoV-2 is of the memory type. In addition, it shows that this reaction occurs with almost all individuals, and particularly also with those who experience no manifest clinical symptoms.

The goal of the vaccination is to stimulate production of antibodies to SARS-CoV-2, but we now know that such antibodies can and will be rapidly generated by everyone upon the slightest viral challenge, even without vaccination.

Severe lung infections always take many days to develop, which means that if the antibodies generated by the memory response are needed, they will arrive on time. Therefore, vaccination is unlikely to provide significant benefit with respect to the prevention of severe lung infection.

Discovery 4: Rapid increase of spike protein antibodies after the second injection of mRNA vaccines

IgG and IgA antibody titres were monitored before vaccination and after the first and the second injection of mRNA vaccines [3]. Antibody titres rose with some delay after the first injection, then plateaued, but rose again very shortly after the second injection.

Significance. Even though the antibody response to the first injection is of the memory type, the small time lag after the injection may mitigate adverse reactions, because the abundance of spike protein on the cells in the blood vessel walls and in other tissues may have already passed its peak when the antibodies arrive.

The situation changes dramatically with the second injection. Then the spikes are produced and protrude into the bloodstream that is already swarming with both reactive lymphocytes and antibodies. The antibodies will cause the complement system [9,10] and also neutrophil granulocytes to attack the spike protein-bearing cells. The possible consequences of all-out self-attack by the immune system are frightening.

Antibody-dependent enhancement of disease

As described, memory-type immune responses ensure the rapid rise of antibody titres after initial exposure to SARS-CoV-2, rendering the benefit of vaccine-induced antibody response exceedingly doubtful. Regardless, we should not assume that high antibody titres against SARS-CoV-2 will always improve the clinical outcome. With several virus families—in particular with Dengue virus, but also with coronaviruses—antibodies can aggravate rather than mitigate disease. This occurs because certain cells of the immune system take up antibody-tagged microbes and destroy them. If a virus particle to which antibodies have bound is taken up by such a cell, but it then manages to evade destruction, it may instead start to multiply within the cell. Overall, the antibody will then have enhanced the replication of the virus. Clinically, this antibody-dependent enhancement (ADE) can cause a hyperinflammatory response (a “cytokine storm”) that will amplify the damage to the lungs, liver and other organs of our body.

Attempts to develop vaccines to the original SARS virus, which is closely related to SARS-CoV-2, repeatedly failed due to ADE. The vaccines did induce antibodies, but when the vaccinated animals were subsequently infected with the virus, they became more ill than the unvaccinated controls (see e.g. [11]). The possibility of ADE was not adequately addressed in the clinical trials on any of the COVID-19 vaccines. It is therefore prudent to avoid the danger of inducing ADE through vaccination and instead rely on proven forms of treatment [12] for dealing with clinically severe COVID-19 disease.

Conclusion

The collective findings discussed above clearly show that the benefits of vaccination are highly doubtful. In contrast, the harm the vaccines do is very well substantiated, with more than 15.000 vaccination-associated deaths now documented in the EU drug adverse events database (EudraVigilance), and over 7.000 more deaths within the UK and the US [13].

ALL PHYSICIANS MUST RECONSIDER THE ETHICAL ISSUES SURROUNDING COVID-19 VACCINATION.

*

Notes

1. Ogata, A.F. et al. (2021) Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients. Clin. Infect. Dis. -:x-x

2. Amanat, F. et al. (2021) SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD and S2. Cell -:x-x

3. Wisnewski, A.V. et al. (2021) Human IgG and IgA responses to COVID-19 mRNA vaccines. PLoS One 16:e0249499

4. Qu, J. et al. (2020) Profile of Immunoglobulin G and IgM Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin. Infect. Dis. 71:2255-2258

5. Le Bert, N. et al. (2020) SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls. Nature 584:457-462

6. Grifoni, A. et al. (2020) Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals. Cell 181:1489-1501.e15

7. Gallais, F. et al. (2021) Intrafamilial Exposure to SARS-CoV-2 Associated with Cellular Immune Response without Seroconversion. Emerg. Infect. Dis. 27:x-x

8. Nielsen, S.S. et al. (2021) SARS-CoV-2 elicits robust adaptive immune responses regardless of disease severity. EBioMedicine 68:103410

9. Magro, C.M. et al. (2020) Docked severe acute respiratory syndrome coronavirus 2 proteins within the cutaneous and subcutaneous microvasculature and their role in the pathogenesis of severe coronavirus disease 2019. Hum. Pathol. 106:106-116

10. Magro, C.M. et al. (2021) Severe COVID-19: A multifaceted viral vasculopathy syndrome. Annals of diagnostic pathology 50:151645

11. Tseng, C. et al. (2012) Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus. PLoS One 7:e35421

12. McCullough, P.A. et al. (2021) Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection. Am. J. Med. 134:16-22

13. Johnson, L. (2021) Official Vaccine Injury and Fatality Data: EU, UK and US.

Author: Centre for Research on Globalization

The Centre for Research on Globalization (CRG) is an independent research and media organization based in Montreal. The CRG is a registered non-profit organization in the province of Quebec, Canada.

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  • Paul Morgan on A Season of Divine DistinctionThomas - I Agree With Carla "THIS WAS ON POINT" - AWESOME Posting!
  • James Bailey on Prophetic chart could be showing macro view of crypto winter aheadI'm glad you asked Cesar because my stuff is constantly a work in progress with lots of warning dreams when I'm not seeing things clearly which is often. I recently saw a 150 point drop which I think…
  • James Bailey on Prophetic chart could be showing macro view of crypto winter aheadYes, I agree Cunny Fred. I think that's when Frank's drop happens. I also agree larger drops will follow afterwards. The lowest SPX number I've seen recently is 1922 but I'm expecting it to eventually…
  • christian on I see a spirit of SUSPICION masquerading as a spirit of discernment – and it’s killing us.thanks !! AMEN
  • Cesar G on Prophetic chart could be showing macro view of crypto winter aheadHi James, But you are expecting the SPX to drop to around 3990 this week before another leg up to your higher targets 4200s and 4300s? Right now the SPX is around 4110-4115 with 1 hour and 30 minutes…
  • Joe on “I will complete My promise to My Chosen…”Watch the waters As the waters will fall In July...... For a third straight week flash flooding is a concern in the same areas of the US (msn.com) Is it time?
  • Paul on Large Danish ministry forced to shut down after slanderous attacks from Danish government and news media.You forgot to mention that one of the undercover reporters, mentally ill one when he asked Tørben if he should continue with hes medication, Tørben said NO.
  • Cunny Fred on Prophetic chart could be showing macro view of crypto winter aheadJames, isn't it possible that the -182 point drop that Frank saw might be part of the journey to 3658? One large daily drop might be followed by other drops. It is also possible that the drop that you…
  • James Bailey on Prophetic chart could be showing macro view of crypto winter aheadThanks for sharing those dreams Frank. The bullish pattern for SPX that you felt bummed that it was broken sounds like what I'm expecting for the next month or so with a downturn starting in mid Septe…
  • LovetheLord on America’s Plan for A New World System (words inspired by God)It's okay to laugh, I believe. That part lifted my spirits. We need some few seconds relief from the stress!
  • faith on I remember thinking “Why did I do this? Now I’m going to die.”I have a different take on this dream and in my opinion it's about the crypto market. One needs to ask themselves the significance of her being a red head and going upstairs. What would that scene hav…
  • lisa on America’s Plan for A New World System (words inspired by God)God bless you Caroline and thank you for this word. This confirms what my spirit has been showing me. The christians that believe this can be overturned are going to be very surprised. We are in the e…
  • Carla on A Season of Divine DistinctionThis was on point, thanks for sharing. Passing this on !! 🙏
  • PaulAu on I remember thinking “Why did I do this? Now I’m going to die.”MITIGATION PROTOCOL - FYI. Last year, I had a very interesting visit with a doctor who was recommended by the Covid Medical Network, Australia. Her take on vaccines: She said that they all had side ef…
  • Frank on Prophetic chart could be showing macro view of crypto winter aheadJames, at risk of this getting buried among so many replies here, I did want to share a very clear dream I had a few days ago on the SP500. In my dream I was watching the evening news and saw the dail…
  • James Bailey on Prophetic chart could be showing macro view of crypto winter aheadI had been thinking it was coming soon but received warnings that it's further out on the timeline. I also received an update that the bottom is closer to 3658, not 3690. My current target date is Sep…
  • Nobody on Prophetic dream reveals coming crash in crypto currency pricesWell, can't say for sure, but need to bring it to your attention that, there is a chance your dream may be about to unfold in a month or 2 in this mid-late summer 2022 ..... your dream did mention an…
  • Katie on Liars, Propagandists and The Great ResetThe evil woman spreading the psudeo psychology to these saps are the real villains
  • N.Newton on Prophetic dream shows Bitcoin stuck in heavy trafficIt could be next summer but I feel something weird going to happen soon. There must be a reason why CCP banned BTC. If this hack occurred, it could be catastrophic. 😎God bless
  • Phil - Sydney on I remember thinking “Why did I do this? Now I’m going to die.”Thanks James I took the jab because I had major expenses and ongoing mortgage payments. Transport NSW would not let me work without the jab. Thanks the Lord that I have been kept well. This policy is…

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