{"id":261937,"date":"2024-03-08T17:01:45","date_gmt":"2024-03-08T22:01:45","guid":{"rendered":"https:\/\/z3news.com\/w\/?p=261937"},"modified":"2024-04-08T17:25:05","modified_gmt":"2024-04-08T21:25:05","slug":"popular-acne-treatments-used-by-millions-of-teens-contain-high-levels-of-chemical-linked-to-leukemia","status":"publish","type":"post","link":"https:\/\/z3news.com\/w\/popular-acne-treatments-used-by-millions-of-teens-contain-high-levels-of-chemical-linked-to-leukemia\/","title":{"rendered":"Popular Acne Treatments Used by Millions of Teens Contain High Levels of Chemical Linked to Leukemia"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-261945\" src=\"https:\/\/z3news.com\/w\/wp-content\/uploads\/2024\/04\/wepik-teenage-girl-with-acne-2-scaled.jpg\" alt=\"\" width=\"2560\" height=\"1463\" srcset=\"https:\/\/z3news.com\/w\/wp-content\/uploads\/2024\/04\/wepik-teenage-girl-with-acne-2-scaled.jpg 2560w, https:\/\/z3news.com\/w\/wp-content\/uploads\/2024\/04\/wepik-teenage-girl-with-acne-2-350x200.jpg 350w, https:\/\/z3news.com\/w\/wp-content\/uploads\/2024\/04\/wepik-teenage-girl-with-acne-2-600x343.jpg 600w, https:\/\/z3news.com\/w\/wp-content\/uploads\/2024\/04\/wepik-teenage-girl-with-acne-2-150x86.jpg 150w, https:\/\/z3news.com\/w\/wp-content\/uploads\/2024\/04\/wepik-teenage-girl-with-acne-2-768x439.jpg 768w, https:\/\/z3news.com\/w\/wp-content\/uploads\/2024\/04\/wepik-teenage-girl-with-acne-2-1536x878.jpg 1536w, https:\/\/z3news.com\/w\/wp-content\/uploads\/2024\/04\/wepik-teenage-girl-with-acne-2-2048x1170.jpg 2048w, https:\/\/z3news.com\/w\/wp-content\/uploads\/2024\/04\/wepik-teenage-girl-with-acne-2-50x29.jpg 50w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><\/p>\n<hr \/>\n<p><em>An independent lab petitioned the U.S. Food and Drug Administration to recall popular prescription and over-the-counter acne treatments after testing showed the products contained \u201cunacceptably high\u201d levels of benzene, a chemical linked to cancer.<\/em><\/p>\n<hr \/>\n<p>High levels of benzene, a chemical linked to cancer, can form in many\u00a0<a href=\"https:\/\/www.statista.com\/statistics\/448473\/leading-us-acne-brands\/\" target=\"_blank\" rel=\"nofollow\">popular acne treatments<\/a>\u00a0containing\u00a0<a href=\"https:\/\/www.valisure.com\/valisure-newsroom\/valisure-detects-benzene-in-benzoyl-peroxide\" target=\"_blank\" rel=\"nofollow\">benzoyl peroxide<\/a>, according to a new report by independent testing laboratory Valisure.<\/p>\n<p>Valisure tested dozens of prescription and over-the-counter products, including popular brands Proactiv, Clinique,\u00a0<a href=\"https:\/\/www.bloomberg.com\/news\/articles\/2024-03-06\/cancer-causing-chemical-found-in-acne-creams-including-proactiv-clearasil\" target=\"_blank\" rel=\"nofollow\">Clearasil<\/a>\u00a0and Target Corp.\u2019s Up &amp; Up, and found they can contain \u201cunacceptably high\u201d levels of the carcinogen.<\/p>\n<p>Testing also revealed that benzene levels increase when the products are handled or stored at higher temperatures \u2014 such as left in a hot car or stored in a steamy bathroom.<\/p>\n<p>The lab\u00a0<a href=\"https:\/\/assets-global.website-files.com\/6215052733f8bb8fea016220\/65e8560962ed23f744902a7b_Valisure%20Citizen%20Petition%20on%20Benzene%20in%20Benzoyl%20Peroxide%20Drug%20Products.pdf\" target=\"_blank\" rel=\"nofollow\">filed a Citizen Petition<\/a>\u00a0with the U.S. Food and Drug Administration (FDA), sharing the results of its analysis and asking the FDA to recall the products and suspend their sales while regulators investigate the issue further.<\/p>\n<p>Acne is one of the most common skin conditions in the U.S., affecting up to\u00a0<a href=\"https:\/\/www.prnewswire.com\/news-releases\/american-academy-of-dermatology-issues-updated-guidelines-for-the-management-of-acne-302049553.html\" target=\"_blank\" rel=\"nofollow\">50 million people per year<\/a>\u00a0in the U.S. Approximately\u00a0<a href=\"https:\/\/health.ucdavis.edu\/blog\/cultivating-health\/what-causes-acne-and-how-do-i-treat-it\/2022\/08\" target=\"_blank\" rel=\"nofollow\">85% of adolescents<\/a>\u00a0experience the condition at some point.<\/p>\n<p>Acne medications containing benzoyl peroxide, which breaks down into benzene, are commonly recommended by\u00a0<a href=\"https:\/\/www.healthychildren.org\/English\/health-issues\/conditions\/skin\/Pages\/What-Causes-Acne.aspx\" target=\"_blank\" rel=\"nofollow\">dermatologists<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.webmd.com\/skin-problems-and-treatments\/acne\/acne-treatments-that-work\" target=\"_blank\" rel=\"nofollow\">health websites<\/a>\u00a0as an easily accessible over-the-counter treatment.<\/p>\n<p>The\u00a0<a href=\"https:\/\/www.jaad.org\/article\/S0190-9622(23)03389-3\/fulltext\" target=\"_blank\" rel=\"nofollow\">American Academy of Dermatology guidelines<\/a>\u00a0strongly recommend benzoyl peroxide for treating acne topically.<\/p>\n<p><a href=\"https:\/\/emergency.cdc.gov\/agent\/benzene\/basics\/facts.asp\" target=\"_blank\" rel=\"nofollow\">Benzene<\/a>, long known to be carcinogenic, is a popular chemical solvent commonly used in\u00a0<a href=\"https:\/\/childrenshealthdefense.org\/defender_category\/big-chemical\/\" target=\"_blank\" rel=\"nofollow\">chemical<\/a>\u00a0and\u00a0<a href=\"https:\/\/childrenshealthdefense.org\/defender_category\/big-pharma\/\" target=\"_blank\" rel=\"nofollow\">pharmaceutical industries<\/a>\u00a0and found in trace amounts in substances ranging from cleaning products to cigarette smoke and\u00a0<a href=\"https:\/\/childrenshealthdefense.org\/defender\/shell-polymers-monaca-plastics-plant-toxic-chemicals-cd\/\" target=\"_blank\" rel=\"nofollow\">gasoline<\/a>. It evaporates quickly, so much human exposure can come from the air.<\/p>\n<p>According to the World Health Organization, \u201c<a href=\"https:\/\/www.who.int\/publications\/i\/item\/WHO-CED-PHE-EPE-19.4.2\" target=\"_blank\" rel=\"nofollow\">there\u2019s no safe level<\/a>\u201d of exposure to benzene in the air we breathe.<\/p>\n<p>Breathing or otherwise absorbing benzene over time can lead to\u00a0<a href=\"https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/frequently-asked-questions-benzene-contamination-drugs\" target=\"_blank\" rel=\"nofollow\">leukemia and other blood disorders<\/a>, according to the FDA.<\/p>\n<blockquote class=\"twitter-tweet\">\n<p dir=\"ltr\" lang=\"en\">\u201cValisure, a New Haven, Conn.-based testing laboratory, filed a petition with the Centers for Disease Control and Prevention which said that it tested 66 different products whose main ingredient is benzoyl peroxide, a topical antiseptic found in creams and face washes that are\u2026 <a href=\"https:\/\/t.co\/69qBP4NY5P\" target=\"_blank\" rel=\"nofollow\">pic.twitter.com\/69qBP4NY5P<\/a><\/p>\n<p>\u2014 Chief Nerd (@TheChiefNerd) <a href=\"https:\/\/twitter.com\/TheChiefNerd\/status\/1765709275169476860?ref_src=twsrc%5Etfw\" target=\"_blank\" rel=\"nofollow\">March 7, 2024<\/a><\/p><\/blockquote>\n<p><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>\n<p>Over the last several years Valisure also identified\u00a0<a href=\"https:\/\/www.dermatologytimes.com\/view\/carcinogen-found-in-multiple-sunscreens\" target=\"_blank\" rel=\"nofollow\">high levels of benzene in sunscreen<\/a>, hand sanitizers and other consumer products, leading the\u00a0<a href=\"https:\/\/www.fda.gov\/drugs\/pharmaceutical-quality-resources\/fda-alerts-drug-manufacturers-risk-benzene-contamination-certain-drugs\" target=\"_blank\" rel=\"nofollow\">FDA to alert drug manufacturers<\/a>\u00a0and recommend against the use of benzene in pharmaceutical products.<\/p>\n<p><a href=\"https:\/\/recalls-rappels.canada.ca\/en\/alert-recall\/ombrelle-garnier-complete-dry-mist-spray-sunscreen-recalled-due-elevated-benzene\" target=\"_blank\" rel=\"nofollow\">Health Canada recalled<\/a>\u00a0some sunscreens. Companies including Johnson &amp; Johnson, Unilever and Procter &amp; Gamble Co. have also\u00a0<a href=\"https:\/\/www.washingtonpost.com\/wellness\/2023\/02\/01\/benzene-aerosol-recalls-sunscreen-shampoo\/\" target=\"_blank\" rel=\"nofollow\">recalled aerosol sunscreens<\/a>,\u00a0<a href=\"https:\/\/www.dermatologytimes.com\/view\/procter-gamble-issue-voluntary-recall-of-certain-old-spice-secret-products\" target=\"_blank\" rel=\"nofollow\">antiperspirants<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.dermatologytimes.com\/view\/unilever-issues-voluntary-recall-for-popular-dry-shampoo-brands\" target=\"_blank\" rel=\"nofollow\">dry shampoos<\/a>.<\/p>\n<p>While those products contained high levels of benzene because of impurities from contaminated ingredients,\u00a0<a href=\"https:\/\/www.valisure.com\/valisure-newsroom\/valisure-detects-benzene-in-benzoyl-peroxide\" target=\"_blank\" rel=\"nofollow\">Valisure President David Light<\/a>\u00a0said in a statement, \u201cThe benzene in benzoyl peroxide products is coming from the benzoyl peroxide itself, sometimes at hundreds of times the conditional FDA limit.\u201d<\/p>\n<p>\u201cThis means the problem broadly affects benzoyl peroxide products, both prescription and over-the-counter, and necessitates urgent action,\u201d he added.<\/p>\n<p>Valisure tested 66 benzoyl peroxide products, including creams, lotions, gels, washes, liquids and bars.<\/p>\n<p><a href=\"https:\/\/www.fda.gov\/drugs\/pharmaceutical-quality-resources\/fda-alerts-drug-manufacturers-risk-benzene-contamination-certain-drugs\" target=\"_blank\" rel=\"nofollow\">FDA guidelines<\/a>\u00a0allow up to two parts per million of benzene. Several of the products tested showed benzene levels well above two parts per million. Those levels jumped to tens or hundreds of times the allowable level when products were tested at higher temperatures designed to replicate the conditions in which they might be transported or stored.<\/p>\n<p><a href=\"https:\/\/www.dermatologytimes.com\/authors\/christopher-g-bunick-md-phd\" target=\"_blank\" rel=\"nofollow\">Christopher Bunick, M.D., Ph.D.<\/a>, associate professor of dermatology at the Yale University School of Medicine and physician-scientist at Yale Dermatology, told\u00a0<a href=\"https:\/\/childrenshealthdefense.org\/defender\/\" target=\"_blank\" rel=\"nofollow\">The Defender<\/a>\u00a0that benzoyl peroxide is susceptible to free radicals or oxidants, which cause it to break down into different chemicals, including benzene when exposed to heat.<\/p>\n<p>Among products with the\u00a0<a href=\"https:\/\/www.dermatologytimes.com\/view\/breaking-news-benzene-found-in-various-acne-products-valisure-files-petition-with-fda-to-recall-treatments\" target=\"_blank\" rel=\"nofollow\">highest benzene levels<\/a>\u00a0was Proactiv\u2019s 2.5% benzoyl peroxide cream, manufactured by Taro Pharmaceuticals, which contained 1,761 parts per million of benzene.<\/p>\n<p>Target\u2019s Up &amp; Up 2.5% benzoyl cream had 1,598 parts per million; Estee Lauder\u2019s Clinique 2.5% benzoyl peroxide cream had 401 parts per million; Reckitt Benckiser Group\u2019s Clearasil 10% benzoyl peroxide cream had 308 parts per million, and Walgreens 10% benzoyl peroxide cream had 114 parts per million.<\/p>\n<p>The lab also found high levels of benzene in La Roche-Posay\u2019s benzoyl peroxide cream, Sandra Lee\u2019s benzoyl peroxide lotion, Neutrogena\u2019s benzoyl peroxide gel, CeraVe\u2019s benzoyl peroxide cream and many others.<\/p>\n<p>The researchers also tested for benzene in the air surrounding the products and found that even an unopened Proactiv product leaked high levels of benzene when kept at 104 degrees Fahrenheit for just under 17 hours.<\/p>\n<p>This shows that benzene \u201ccan leak out of some product packages and pose a potential inhalation risk,\u201d the company wrote.<\/p>\n<p>\u201cValisure\u2019s findings are significant for the skincare industry,\u201d Bunick said, citing several reasons:<\/p>\n<p>\u201cFirst, manufacturers must maintain certain quality and safety standards as mandated by the FDA. Current benzoyl peroxide products do not meet that standard, especially with regards to stability over time and temperature.<\/p>\n<p>\u201cSecond, \u2026 benzene is a well-established carcinogen in the same highest danger category as asbestos, lead and formaldehyde.<\/p>\n<p>\u201cThird, it is less clear to fully comprehend the health implications of benzene exposure, because the cancer-causing effect may take decades to manifest. It is a similar scenario to sun exposure, where sunburns in one\u2019s youth potentially lead to skin cancers in adulthood, sometimes 20-40 years after exposure.<\/p>\n<p>\u201cLastly,\u00a0<a href=\"https:\/\/www.atsjournals.org\/doi\/abs\/10.1164\/rccm.202308-1440OC\" target=\"_blank\" rel=\"nofollow\">a new report<\/a>\u00a0out of the U.K. showed that low-level benzene exposure (at levels below 1 part per million, which is less than what is seen in many benzoyl peroxide products) increased risk of all-cause mortality, cardiovascular disease and multiple cancers, including hematologic and lung.\u201d<\/p>\n<p>Valisure also tested products containing other ingredients, such as\u00a0<a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/salicylic-acid-topical-route\/proper-use\/drg-20066030\" target=\"_blank\" rel=\"nofollow\">salicylic acid<\/a>\u00a0or\u00a0<a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a604001.html\" target=\"_blank\" rel=\"nofollow\">adapalene<\/a>. Those products had benzene levels that were either undetectable or below the FDA\u2019s current limit of 2 parts per million, the lab reported in its Citizen Petition. Only the products containing benzoyl peroxide contained high levels of benzene.<\/p>\n<p>The FDA, Est\u00e9e Lauder and Reckitt did not immediately respond to The Defender\u2019s request for comment.<\/p>\n<p>An FDA spokesperson confirmed in a statement Wednesday and\u00a0<a href=\"https:\/\/www.cnn.com\/2024\/03\/06\/health\/benzene-acne-products-valisure\/index.html\" target=\"_blank\" rel=\"nofollow\">reported by CNN<\/a>\u00a0that the agency had received the petition and would respond.<\/p>\n<p>\u201cSuch data must be verified as accurate and reproducible before it can be utilized to make regulatory decisions such as recommending product sale suspensions and recalls,\u201d the statement said.<\/p>\n<p>Valisure\u2019s Light has a\u00a0<a href=\"https:\/\/patents.google.com\/patent\/WO2023177625A1\/en?inventor=%22david+light%22&amp;oq=inventor:+%22david+light%22&amp;sort=new\" target=\"_blank\" rel=\"nofollow\">patent application<\/a>\u00a0pending on formulations and techniques to reduce the rate of benzyne formation from benzoyl peroxide breakdown,\u00a0<a href=\"https:\/\/www.bloomberg.com\/news\/articles\/2024-03-06\/cancer-causing-chemical-found-in-acne-creams-including-proactiv-clearasil\" target=\"_blank\" rel=\"nofollow\">Bloomberg reported<\/a>, although the patents have not yet been granted.<\/p>\n<p>The lab is also known for its investigation into Zantac, which the\u00a0<a href=\"https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-requests-removal-all-ranitidine-products-zantac-market\" target=\"_blank\" rel=\"nofollow\">FDA pulled from the market<\/a>\u00a0in 2020 after the lab notified the agency that the drug\u2019s key ingredient,\u00a0<a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a601106.html\" target=\"_blank\" rel=\"nofollow\">ranitidine<\/a>, could expose people to a carcinogenic substance called N-Nitrosodimethylamine. Another lab, Emery Pharma, confirmed the findings. Both labs submitted Citizen Petitions\u00a0<a href=\"https:\/\/www.fiercepharma.com\/manufacturing\/zantac-and-generics-ordered-off-market-by-fda-as-find-it-a-ticking-time-bomb\" target=\"_blank\" rel=\"nofollow\">demanding recall<\/a>.<\/p>\n<hr \/>\n<p><em>Originally published by <a href=\"https:\/\/childrenshealthdefense.org\/defender\/acne-treatment-benzoyl-peroxide-benzene-cancer\/\" target=\"_blank\" rel=\"nofollow\">The Defender \u2014 Children\u2019s Health Defense\u2019s News and Views Website<\/a> under Creative Commons license CC BY-NC-ND 4.0. Please consider <a href=\"https:\/\/childrenshealthdefense.org\/about-us\/sign-up\/\" target=\"_blank\" rel=\"nofollow\">subscribing to The Defender<\/a> or <a href=\"https:\/\/childrenshealthdefense.org\/about-us\/donate\/\" target=\"_blank\" rel=\"nofollow\">donating to Children\u2019s Health Defense<\/a>.<\/em><\/p>\n<hr \/>\n","protected":false},"excerpt":{"rendered":"<p>An independent lab petitioned the U.S. Food and Drug Administration to recall popular prescription and over-the-counter acne treatments after testing showed the products contained \u201cunacceptably high\u201d levels of benzene, a chemical linked to cancer. High levels of benzene, a chemical linked to cancer, can form in many\u00a0popular acne treatments\u00a0containing\u00a0benzoyl peroxide, according to a new report [&hellip;]<\/p>\n","protected":false},"author":1285,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"sfsi_plus_gutenberg_text_before_share":"","sfsi_plus_gutenberg_show_text_before_share":"","sfsi_plus_gutenberg_icon_type":"","sfsi_plus_gutenberg_icon_alignemt":"","sfsi_plus_gutenburg_max_per_row":"","_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":"","_ppma_block_editor_authors":""},"categories":[1326,1275],"tags":[],"ppma_author":[1253],"class_list":["post-261937","post","type-post","status-publish","format-standard","category-benzene","category-cancer","entry","has-post-thumbnail"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.2.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"An independent lab petitioned the U.S. Food and Drug Administration to recall popular prescription and over-the-counter acne treatments after testing showed the products contained \u201cunacceptably high\u201d levels of benzene, a chemical linked to cancer. High levels of benzene, a chemical linked to cancer, can form in many popular acne treatments containing benzoyl peroxide, according to a new report\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Brenda Baletti, Ph.D., Children&#039;s Health Defense\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/z3news.com\/w\/popular-acne-treatments-used-by-millions-of-teens-contain-high-levels-of-chemical-linked-to-leukemia\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 5.0.2.1\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/z3news.com\\\/w\\\/popular-acne-treatments-used-by-millions-of-teens-contain-high-levels-of-chemical-linked-to-leukemia\\\/#article\",\"name\":\"Popular Acne Treatments Used by Millions of Teens Contain High Levels of Chemical Linked to Leukemia | Z3 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