2) Ignoring the risk of infection, given that someone was infected, Acharya et al<\/a>. found \u201cno significant difference in cycle threshold values between vaccinated and unvaccinated, asymptomatic and symptomatic groups infected with SARS-CoV-2 Delta.\u201d<\/p>\n 3) Riemersma et al<\/a>. found \u201cno difference in viral loads when comparing unvaccinated individuals to those who have vaccine \u201cbreakthrough\u201d infections. Furthermore, individuals with vaccine breakthrough infections frequently test positive with viral loads consistent with the ability to shed infectious viruses.\u201d Results indicate that \u201cif vaccinated individuals become infected with the delta variant, they may be sources of SARS-CoV-2 transmission to others.\u201d They reported \u201clow Ct values (<25) in 212 of 310 fully vaccinated (68%) and 246 of 389 (63%) unvaccinated individuals. Testing a subset of these low-Ct samples revealed infectious SARS-CoV-2 in 15 of 17 specimens (88%) from unvaccinated individuals and 37 of 39 (95%) from vaccinated people.\u201d<\/p>\n 4) In a study from Qatar, Chemaitelly et al<\/a>. reported vaccine efficacy (Pfizer) against severe and fatal disease, with efficacy in the 85-95% range at least until 24 weeks after the second dose. As a contrast, the efficacy against infection waned down to around 30% at 15-19 weeks after the second dose.<\/p>\n 5) From Wisconsin, Riemersma et al.<\/a> reported that vaccinated individuals who get infected with the Delta variant can transmit SARS-CoV-2 to others. They found an elevated viral load in the unvaccinated and vaccinated symptomatic persons (68% and 69% respectively, 158\/232 and 156\/225). Moreover, in the asymptomatic persons, they uncovered elevated viral loads (29% and 82% respectively) in the unvaccinated and the vaccinated respectively. This suggests that the vaccinated can be infected, harbor, cultivate, and transmit the virus readily and unknowingly.<\/p>\n 6) Subramanian<\/a> reported that \u201cat the country-level, there appears to be no discernable relationship between percentage of\u00a0population fully vaccinated and new COVID-19 cases.\u201d When comparing 2947 counties in the United States, there were slightly less cases in more vaccinated locations. In other words, there is no clear discernable relationship .<\/p>\n 7) Chau et al<\/a>. looked at transmission of SARS-CoV-2 Delta variant among vaccinated healthcare workers in Vietnams. Of 69 healthcare workers that tested positive for SARS-CoV-2, 62 participated in the clinical study, all of whom recovered. For 23 of them, complete-genome sequences were obtained, and all belonged to the Delta variant. \u201cViral loads of breakthrough Delta variant infection cases were 251 times higher than those of cases infected with old strains detected between March-April 2020\u201d.<\/p>\n 8) In Barnstable, Massachusetts, Brown et al <\/a>found that among 469 cases of COVID-19, 74% were fully vaccinated, and that \u201cthe vaccinated had on average more virus in their nose than the unvaccinated who were infected.\u201d<\/p>\n 9) Reporting on a nosocomial hospital outbreak<\/a> in Finland, Hetem\u00e4li et al. observed that \u201cboth symptomatic and asymptomatic infections were found among vaccinated health care workers, and secondary transmission occurred from those with symptomatic infections despite use of personal protective equipment.\u201d<\/p>\n 10) In a hospital outbreak<\/a> investigation in Israel, Shitrit et al. observed \u201chigh transmissibility of the SARS-CoV-2 Delta variant among twice vaccinated and masked individuals.\u201d They added that \u201cthis suggests some waning of immunity, albeit still providing protection for individuals without comorbidities.\u201d<\/p>\n 11) In the UK COVID-19 vaccine Surveillance Report for week #42<\/a>, it was noted that there is \u201cwaning of the N antibody response over time\u201d and \u201cthat N antibody levels appear to be lower in individuals who acquire infection following 2 doses of vaccination.\u201d The same report (Table 2, page 13), shows the in the older age groups above 30, the double vaccinated persons have greater infection risk than the unvaccinated, presumably because the latter group include more people with stronger natural immunity from prior Covid disease. As a contrast, the vaccinated people had a lower risk of death than the unvaccinated, across all age groups, indicating that vaccines provide more protection against death than against infection.<\/p>\n 12) In Israel, Levin et al<\/a>. \u201cconducted a 6-month longitudinal prospective study involving vaccinated health care workers who were tested monthly for the presence of anti-spike IgG and neutralizing antibodies\u201d. They found that \u201csix months after receipt of the second dose of the BNT162b2 vaccine, humoral response was substantially decreased, especially among men, among persons 65 years of age or older, and among persons with immunosuppression.\u201d<\/p>\n 13) In a study from New York State, Rosenberg et al.<\/a> reported that \u201cDuring May 3\u2013July 25, 2021, the overall age-adjusted vaccine effectiveness against hospitalization in New York was relatively stable 89.5%\u201395.1%). The overall age-adjusted vaccine effectiveness against infection for all New York adults declined from 91.8% to 75.0%.\u201d<\/p>\n 14) Suthar et al.<\/a> noted that \u201cOur data demonstrate a substantial waning of antibody responses and T cell immunity to SARS-CoV-2 and its variants, at 6 months following the second immunization with the BNT162b2 vaccine.\u201d<\/p>\n 15) In a study from Ume\u00e5 University in Sweden, Nordstr\u00f6m<\/a> et al. observed that \u201cvaccine effectiveness of BNT162b2 against infection waned progressively from 92% (95% CI, 92-93, P<0\u00b7001) at day 15-30 to 47% (95% CI, 39-55, P<0\u00b7001) at day 121-180, and from day 211 and onwards no effectiveness could be detected (23%; 95% CI, -2-41, P=0\u00b707).\u201d<\/p>\n
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