In a preprint article posted May 26 on Research Square, the team reported that the problem lies with the adenovirus vectors used by the two vaccines to deliver genetic instructions inside cells. The researchers said that due to the mechanisms involved in this type of technology, mutant versions of the spike protein are generated in the nucleus and are then secreted outside of cells. They believe that it is these mutant proteins that trigger the blood clots in healthy people who received the AstraZeneca or J&J vaccines.
Adenovirus-based vaccines and their adverse effects
The formation of blood clots in the brain’s venous sinuses — also known as cerebral venous sinus thrombosis (CVST) — was first associated with the AstraZeneca vaccine. In Europe, around 150 cases of this thromboembolic event were reported after different countries successfully administered about 17 million doses of the said vaccine.
Under normal circumstances, CVST is considered a rare form of stroke, affecting only five people in one million each year. Studies show that since the middle of the 20th century, the mortality rate of CVST has gone down from 50 percent to a mere 8.3 percent due to advances in modern medicine. But since mass vaccinations have begun, CVST has caused the death of one-third of all affected vaccinated individuals in Germany alone.